Animal Health & Discovery

The experienced, best-in-class Animal Health Division at Avista Pharma Solutions has a proven track record of identifying new compounds and advancing them from drug lead to late-stage development in collaboration with our animal health partners.

Anti-Parasitic Discovery

With a core expertise in the discovery of novel, anti-parasitic drugs, Avista Pharma has established a state-of the art screening platform for the evaluation of large chemical libraries or focused compound collections against a broad spectrum of parasites relevant to key animal health markets. These assays include over 30 unique, commercially-important ectoparasites (fleas, ticks, flies), endoparasites (intestinal worms, heartworm) and protozoans (leishmania, cryptosporidium, trypanosomes), including strains resistant to major classes of antiparasitic drugs that are already on the market. The highly recognized discovery team at Avista Pharma has designed and implemented proprietary screens and strategies to progress compounds from in vitro assays into in vivo efficacy and safety models in preparation for, and support of, clinical studies.

Target Product Synthesis

Each lead optimization process is tailored to a specific Target Product Profile for the appropriate disease indication. Avista Pharma’s multidisciplinary discovery teams (i.e consisting of biology, chemistry and DMPK scientists) advance compound series from preclinical into clinical candidate nomination stage. This world-class team of scientists is experienced in the unique requirements of animal health drugs and markets. Medicinal chemists design and synthesize new compounds to optimize biological activity and physicochemical properties. Parasitologists develop assays to test the new compounds in order to understand effects on the parasites of interest. DMPK scientists perform assays and studies to understand the disposition and pharmacokinetics of the compounds, with particular focus on the behavior of the compounds in key market species (dogs, cats, livestock). The integration of these disciplines, coupled with the team’s particular expertise in animal health, enables the design and selection of new chemical entities that meet the market needs of clients and anticipate areas for future strategic collaboration.

 

Avista Pharma’s Best-in-Class Animal Health Capabilities Include:

 

  • Integrated discovery teams to drive the drug discovery process
  • Biologists, Chemists and DMPK Scientists
  • Parasiticide Discovery (endoparasites, ectoparasites, protozoans, and disease vectors)
  • Novel whole organism assays
  • Developed and validated screening cascades
  • Compound selection and workflow management
  • In vitro screening
  • In vivo models
  • Network of leading animal health experts